Endocrine Abstracts

Introduction: Cytokeratin-19 (CK19), p53 and Ki-67 are some of the proposed markers for differentiating benign from malignant thyroid tumors.Material and method: We evaluated the tissue expression of the three markers in 60 thyroid lesions including: 8 cases of nodular hyperplasia (NH), 16 follicular adenomas (FA), 26 papillary carcinomas (PC) and 10 follicular carcinomas (FC). Tissue sections fixed in formalin and embedded in paraffin were immunohistoch...

Carcinoid tumors are distinct neuroendocrine neoplasms with characteristic histological, clinical and biological features.Material and methods: An extremely rare case of a primary carcinoid tumor arising in a mature cystic teratoma is reported. A 23-year-old woman was admitted with pain in the lower abdomen and for further examination of a tumor in the left anexa. Transabdominal ultrasonography demonstrated a cystic mass measuring 110/70 mm, with irregul...

Mutations in the RET protooncogene cause familial cases of medullary thyroid cancer, which in some cases coexists with pheochromocytoma and primary hyperparathyreoidism as the MEN2A syndrome.Aim of the study: Evaluation of frequency of pheochromocytomas and their clinical course in the RET protooncogene mutations carriers.Material: One hundred and seventy nine patients, among them 109 probands and 70 family members in...

Introduction: The combined influence of risk factors on osteoporosis being known, the problem whether it is correctly identified and quantified arises, aiming to the improvement of populational screening. The correct judgment related to osteoporotic pathology refers to fracture risk assessment.Materials and methods: We investigated 2149 women aged 20–91, without treatment for osteoporosis, for anthropometric, anamnestic and bone densitometry feature...

Purpose: The purpose of this study was to evaluate the histologic spectrum of stromal–epithelial patterns of invasion in ovarian serous and mucinous tumors of low malignant potential.Materials and methods: We retrospectively analyzed 31 cases of borderline ovarian serous and mucinous tumors diagnosed of the Pathology Department of County Hospital Timisoara in a period of 5 years, between 2003 and 2007. Epithelial architecture, the patterns of stroma...

Introduction: The value of microvessel density (MVD) as a prognostic factor in thyroid carcinomas, and its role in the development of metastasis, remain controversial.Aim: Determination of the relationship between MVD, the histological subtype of PTC, the presence or absence of metastasis in cervical lymph nodes (LN), the recurrence of the disease and AMES prognostic index.Material and method: The study included 32 patients with PT...

IntroductionSilent corticotroph adenoma represent an uncommon subtype of nonfunctioning adenoma, immunoreactive for ACTH, without clinical or biochemical evidence of hypercortisolism and unclear pathogenesis. Usually, they present with local mass effect (visual deterioration being the most common) and endocrine dysfunctions. They carry a more aggressive behavior, particularly upon earlier recurrence.Case presentation<p class="a...

Background: Although recombinant human TSH (rhTSH) is widely used to aid radioiodine treatment of differentiated thyroid cancer (DTC), however, there are data on its effectivness in children and adolescents with DTC.The aim of our retrospective study was to evaluate effectiveness and safety of rhTSH aided radioiodine treatment in DTC patients 18 years of age or younger.Material and Methods: Fifty five children/adolescents (median a...

Proto-oncogene RET encodes a receptor tyrosine kinase. Germline point mutations of RET result in development of multiple endocrine neoplasia, type 2 (MEN 2). MEN 2 phenotype is correlated with intragene localization of germline mutation. The disease has three main subtypes, MEN 2A, MEN 2B and FMTC. Each of subtypes is associated with high risk of medullary thyroid cancer, MEN 2A and MEN 2B with 50% risk of pheochromocytoma, MEN 2A with 15–30% risk of primary hyperparathyr...

Background: Although neuroendocrine tumours (NET) constitute a very heterogeneous group, most of them express somatostatin receptors that enable treatment with somatostatin analogues(SA), which proved to be effective both as bio- or radiopeptide therapy. However, little is now about combining this two treatment modalities.The aim of our prospective study was to evaluate results of radiolabeled somatostatin analogues (PRRT) with or without long lasting ‘cold’ SA as co...